The Institute for Systems Biology is a premier, nonprofit research organization based in Seattle, Washington. It was founded in 2000 by Leroy Hood, a world-renowned systems biologist; Alan Aderem, a leading immunologist; and Ruedi Aebersold, a cutting-edge protein chemist. ISB was established as an untraditional institution, where scientific collaboration could take place across disciplines, where biologists and technologists could commingle, and where the future of research and medicine could take foot. ISB pioneered systems biology, which harnesses and integrates the respective insights of biologists, geneticists, computer scientists, chemists, engineers, mathematicians, immunologists and others to answer some of society’s most challenging questions related to health and the environment.