The primary goal of the Cystic Fibrosis Research and Translation Center (CFRTC) is to be a world leader in clinical-translational science in cystic fibrosis (CF), spanning from early drug development to dissemination into the CF community. Through the strength of the Microbiology, Genomics, Host Response and Clinical Cores as well as the pilot program, we strive to understand the bacterial-host interactions in the pulmonary and gastrointestinal tracts of patients with CF. We focus on interdisciplinary studies and encourage new investigators in digestive diseases, nutrition and metabolism, and inflammation.