23 Oct Drug Excretion in Breast Milk
This study explores how medications enter breast milk, which is not yet fully understood. We will investigate this process using the medication cimetidine, an over-the-counter heartburn medication that is safe for use while breastfeeding and has few side effects.
Participants will give consent during pregnancy, but all study activities will occur after delivery.
Participation in the study involves three separate study days, each lasting 12-13 hours. These days will be scheduled at 3-5 weeks, 3-4 months, and 6-8 months postpartum. On each study day, participants will take a single dose of cimetidine and provide samples of blood, urine, and breast milk. Participants are welcome to bring their infants to the study days.
Participants who complete all study procedures will receive $700 in compensation.
Participant Eligibility
Inclusion Criteria:
Between the ages of 18-50 years old
Generally healthy
Planning to lactate for at least six months postpartum
Able to provide written informed consent
Exclusion Criteria:
Multiple gestation (twins, triplets, etc.)
Hypersensitivity to cimetidine
Receiving medication(s) known to interact with cimetidine
Known kidney disease
Known liver disease
Inability to fast for 4 hours prior to the study
Use of tobacco or other nicotine containing products
Contact
Madison Navarro
(206) 543-5600
Additional Study Details
Full Study Title
Drug Excretion in Breast Milk
Investigator(s)
Dr. Mary Hebert, PharmD, FCCP
Dr. Joanne Wang, PhD
Dr. Emily Fay, MD
Accepts Healthy Volunteers?
Yes
Study Site(s)
University of Washington
1959 NE Pacific St
Seattle, Washington 98195
