CHARTER Plus

10 Jun CHARTER Plus

We are conducting the study to learn more about the physical and mental effects of infection with human immunodeficiency virus (HIV), aging, substance use and the possible effects of antiretroviral medications (ARVs). Participation in the study may or may not benefit you directly, but may result in new knowledge that may help others.

Participant Eligibility

1. Aged 18 years and older

2. Possess the capacity to provide informed consent to assessment procedures. Individuals unable to provide consent will not be enrolled.

3. Fall into one of these subgroups:
a. Subgroup 1: Completion of a 12-year follow-up visit in the recently completed CHARTER Aging study. Those who previously completed the LP or neuroimaging assessments will be prioritized.

b. Subgroup 2: Diagnosed with HIV within the past 10 years and on suppressive ART.

c. Subgroup 3: HIV negative participants. Absence of HIV will be determined using the MedMira Rapid Test (Halifax, Nova Scotia, Canada). If the result differs from the participant’s self-report, a confirmatory test (HIV RNA, antigen/antibody test, HIV RNA) will be performed.

Participants must have at least one of the following:
(1) high risk sexual or drug use (NIDA priorities) activity141,
(2) use of pre-exposure prophylaxis (PrEP),
(3) history of a sexually transmitted infection (e.g., syphilis).

d. Subgroup 4: Aged 50 years or older who have a family history of dementia, including Alzheimer’s Disease (AD) and AD-related disorders (ADRD).

Contact

Gabrielle Wood
(206) 773-7129