In collaboration with Partnerships for Native Health at the University of Washington, the Native American Clinical Research Network (NACRN) is a growing network of community partners interested in engaging in research, including a primary care practice electronically linked with Data QUEST. We have engaged an interdisciplinary group of researchers and clinicians who are devoted to understanding and promoting quality healthcare in underserved populations. Research programs are varied and inclusive, focusing on diverse populations as well as innovative research strategies. Our collaborator, Partnerships for Native Health, conducts community-centered research, training, education, and outreach to improve the health and quality of life of American Indian and Alaska Native (AI/AN) populations. NACRN has over 70 affiliated clinic and community partners across the WWAMI region that serve AI/ANs.